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Principal Investigator (Lu Xie, Ph.D.)

 

 

xielu Lu XIE

Ph.D.,M.D.,Professor,Vice Director,

Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology.

1278 Keyuan Road, Floor 2, Shanghai 201203, P.R.China.

Tel: +86-21-20283705; Email: luxiex2017@outlook.com

Website:http://www.scbit.org; https://www.researchgate.net/profile/Lu_Xie4



Chronology of Employment:

2012.4-present Vice Director, Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology. 

2010.4-present Professor, Principal Investigator of Translational Medicine Research Group, Shanghai Center for Bioinformation Technology.

2008.6-2012.3 Assistant Director, Shanghai Center for Bioinformation Technology.

2005.8-2010.3 Associate Professor, Principal Investigator of Translational Medicine Research Group, Shanghai Center for Bioinformation Technology.

2000.8-2005.7 Research Fellow, Vanderbilt-Ingram Cancer Center, Dr. Harold L. Moses (Founder Director of the Cancer Center) Lab, Vanderbilt University, Nashville, Tennessee, USA.

1994.6-1996.7 Research Assistant, Laboratory of Tumor Immunology Biology, Cancer Research Institute, Hunan Medical University, Changsha, China. 

 

 Education:

       1996.8-2000.7 Ph.D., Major—Molecular Carcinogenesis, Cancer Research Institute, Xiang-Ya Medical School of Central South University, Changsha, China, mentor: Kaitai Yao, M.D., Professor of Tumor Pathophysiology, member of Chinese Academy of Sciences

       1991.7-1994.5 M.S., Major--Tumor Immunology Biology, Cancer Research Institute, Hunan Medical University, Changsha, China.  

 1985.9-1991.6 M.D., Major--Clinic Medicine, English Medical Class (6-year), Hunan Medical University, Changsha, China.

    Awards:

2019: Shanghai Leading Talents Program.

2014: Shanghai Natural Science Award First Level Prize.

2010: Female Innovation Award of Shanghai City.

2006: Pujiang Talented Personel Research Grant, Shanghai.

2004: Susan-Komen Breast Cancer Research Fundation Scholar-in-Training Award, invited for oral presentation in AACR(American Association for Cancer Research) 95th Annual Meeting, March 27-31, 2004, Orlando, Florida.

2001: The Second Prize of Science and Technology Progression of Hunan Province.

1996: The First Prize of Medical and Health Science Technology Progression of Hunan Province.

    Membership:

2018.12-Present, Committee member, Gene Detection Council, Chinese Biomedical and Biological Technology Association

2015.10-present, Committee member, Bioinformatics Technology Council, Chinese Biomedical and Biological Technology Association.

2012.10-present, Shanghai Society for Bioinformatics. Council member.

2011.4-present, Committee member, Proteomics Committee, Chinese Biochemistry and Molecular Biology Association.

2001-2004, Associate Member of American Association of Cancer Research(AACR).

1998-1999, Active Member of New York Academy of Sciences.

    Current Work Description:

She has been leading multiple national and local key research projects. Her work fields include omics data analyses and integration; tumor immunotherapy; clinical disease modeling and decision making. She is also devoted in constructing bioinformatics platforms for precision medicine, and in training Bioinformatics graduate students.

Research: Protein function studies used to cover protein location, quantitation, post-translational modification and protein-protein interaction, now mainly focus on functional network construction, annotation and integrative analyses. Translational medicine research used to focus on biomarker selection and clinical modeling, now extended to drug repositioning and network medicine. The ultimate goal is to analyze multiple –omics data and clinical data by means of bioinformatics strategy, in order to provide theoretical base and software tools for clinical translation.

Service: Data analyses for genomics, transcriptomics, epigenetics sequencing; clinical modeling for prognosis or treatment outcome; signaling pathway or functional network analysis; database construction; integrative analysis for multiple –omics data.

Software: We provide database and analysis tools for tumor neoantigen, multiple omics data, post-translational modification, cancer differential proteins, phosphorylation mediated signaling network, prognostic molecules and online prognostic modeling, such as:

dbPepNeo: tumor neoantigen peptides

Ineo-Epp: tumor neoantigen immunogenicity prediction

ProGeo-Neo: proteogenomics workflow for neoantigen prediction

OmicsBean-Cancer: cancer multi-omics data analysis and visualization

dbPHCC: prognosis markers and modeling for hepatocellular carcinoma

ShanghaiScore: prognosis and decision making assistance tool for post-surgical patients of hepatocellular carcinoma

dbDEPC3.0: tumor differentially expressed protein biomarkers

SysPTM2.0: comprehensive annotation database for protein post-translational database

SyStemCell: multi-level biomarkers of stem cells

Representative publications:

She has published more than 140 papers, and been cited for over 4200 times. For representative publication full texts please check: https://www.researchgate.net/profile/Lu_Xie4/research

 

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copyright : Shanghai Center for Bioinformation Technology (SCBIT)

address: No.1278 Ke Yuan Road, Floor 2, Shanghai, P.R.C.
Phone: +8621-20283700, Fax: +8621-20283780, Postal Code: 201203, Email: scbit@scbit.org